Novel fluorescent probes improve pyroptosis imaging and aid high-throughput screening of caspase-1 inhibitors.
A novel caspase-1-activatable probe FPy1 has been successfully used for the imaging of caspase-1 or pyroptosis across multiple biological scenarios, encompassing multiscale pyroptosis imaging and high-throughput screening of caspase-1 inhibitors.
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Wang et al. (2025) studied this question.
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