Synthesis of 4-aryl-3,4-dihydrobenzoimidazo compounds shows antioxidant activity, indicating potential health benefits.
4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones were obtained by the reaction of dimethyl malonate (diethyl malonate), aromatic aldehyde, and 1H-benzimidazole-2-amine in methanol (ethanol) in the presence of piperidine for 6 h. Structure of the compounds was confirmed by 1H, 13C NMR spectroscopy and X-ray diffraction analysis. Antioxidant activity of the synthesized compounds was studied.
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N. A. Buzmakova (2025) studied this question.
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