Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers

Seojung Cho; Jumpei Morimoto; Yutaro Saito; Yukiko Nagai; Asuka Sakata; Keitaro Yoshimoto; Mitsuki Tsuruta; Daisuke Miyoshi; Shinsuke Sando; Seojung Cho; Jumpei Morimoto; Yutaro Saito; Yukiko Nagai; Asuka Sakata; Keitaro Yoshimoto; Mitsuki Tsuruta; Daisuke Miyoshi; Shinsuke Sando

doi:10.1039/d5bm01078k

Key Points

This research aims to explore how polymer conjugation affects the properties of aptamers.
Investigated the physicochemical properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers.
Assessed the functional properties of polymer-conjugated aptamers.
Analyzed pharmacokinetics associated with the conjugation.
Polymer conjugation significantly enhances the pharmacokinetics of aptamers.
Physicochemical properties are improved upon conjugation.
Functional properties of aptamers show notable enhancement.

Implication

Research reveals enhanced pharmacokinetics in polymer-conjugated aptamers, suggesting important functional improvements.

Abstract

Polymer conjugation is a common strategy to improve the pharmacokinetics of aptamers, yet its effects on aptamer properties are incompletely understood.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/69255731c0ce034ddc35aa60 https://doi.org/10.1039/d5bm01078k

View Full Paper

Ask AI

Bookmark

Share

Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers

Key Points

Implication

Abstract

Discussion

Cite This Study

Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading