Keyora Integrated Nutritional Modulation of the Redox–NO–Androgen Axis in Male Endocrine, Reproductive, and Metabolic Disorders

Emerging evidence reveals that male endocrine, reproductive, and metabolic disorders—including erectile dysfunction, infertility, benign prostatic hyperplasia, chronic prostatitis, androgenic alopecia, and metabolic syndrome—share a unified upstream pathophysiological mechanism characterized by oxidative stress, nitric oxide (NO) deficiency, androgenic dysregulation, and mitochondrial impairment. This interlinked cascade, defined as the Redox–NO–Androgen Axis, disrupts cellular energy homeostasis, endothelial perfusion, and hormonal balance, leading to multi-organ functional decline across vascular, reproductive, and endocrine systems. This project aims to develop and validate a nutritional systems intervention model capable of reconstructing this axis through multi-nutrient modulation. The study integrates antioxidants (lycopene, vitamins C and E, selenium, zinc), endothelial cofactors (L-arginine, magnesium, folate, B-vitamins), endocrine regulators (saw palmetto, vitamin D₃), and mitochondrial enhancers (Co-Q10, α-linolenic acid, linoleic acid, oleic acid). Collectively, these components target the Nrf2–NF-κB, PGC-1α–SIRT1–AMPK, and NO–eNOS–cGMP signaling pathways that govern oxidative–inflammatory balance, energy metabolism, and androgenic activity. Through a systems-level analysis combining biochemical, molecular, and clinical endpoints, this research seeks to demonstrate how coordinated nutritional modulation of the Redox–NO–Androgen network can restore mitochondrial–endothelial–hormonal homeostasis. The project positions nutritional systems pharmacology as a translational bridge between functional nutrition and precision endocrinology, providing a preventive and restorative framework for male health optimization across lifespan and comorbid conditions.