MALDI mass spectrometry analysis of N -glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling

MinJu Kim; Eun Ju Lee; So-Hee Yoon; Hae Min Park; MinJu Kim; Eun Ju Lee; So-Hee Yoon; Hae Min Park

doi:10.1039/d5ay01494h

January 1, 2025Analytical Methods

MALDI mass spectrometry analysis of N -glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling

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Key Points

MALDI-MS-based analysis enables sensitive measurement of intact N-glycans.
The methodology combines DMTMM-mediated benzylamidation with GP labeling.
This approach provides a reliable means of analyzing glycoproteins.
Further validation may enhance the applicability of this technique.

Implication

MALDI-MS-based analysis enables sensitive measurement of intact N-glycans released from glycoproteins.

Abstract

MALDI-MS-based N -glycan analysis with both DMTMM-mediated benzylamidation and GP labeling allows the sensitive measurement of intact N -glycans released from glycoproteins.

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/69255737c0ce034ddc35aea0 https://doi.org/10.1039/d5ay01494h

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MALDI mass spectrometry analysis of N -glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling

Key Points

Implication

Abstract

Discussion

Cite This Study

MALDI mass spectrometry analysis of N -glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling

Key Points

Implication

Abstract

Discussion

Cite This Study

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