Neuronal-glial interactions in learning and behavior under normal conditions and during oncogenesis

The review examines modern studies of glial-neuronal interactions in the formation of new experiences under normal conditions and in the development of pathology in the brain, in particular, tumor growth. According to modern concepts, glial cells play a key role in synaptic plasticity, regulation of neural activity and memory formation. In the oncological process in the brain, the activity of atypical cells affects the interaction of neurons and glia, changing the functional architecture of the brain, which is not always accompanied by loss of function associated with the area of tumor localization. The analyzed data suggest the presence of mutual adaptation of healthy and atypical cells to co-existence, as well as the possibility of changing the metabolism of tumor cells by specializing neurons.