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Experimental findings show that TDP-43 oligomers induce phase separation and hyperphosphorylation in cells, implying potential roles in neurodegeneration.
D1core oligomers prepared in reversed micelles promote phase separation of the TDP-43 C-terminal domain and induce cytosolic TDP-43 condensates that recruit HSP70 and G3BP1 and exhibit disease-associated hyperphosphorylation.
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Chen et al. (2025) studied this question.
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