Role of Mutations of the and Genes in the Radiation-Induced Response in

In this study, for the first time, information was obtained on the sensitivity of animals with dysfunction of the and genes to chronic irradiation in low doses (20 sGy) and the manifestation of a radioadaptive response in the analyzed mutants. The reaction of mutant genotypes of to irradiation was analyzed in terms of lifespan, fertility, and DNA damage. The experimental results showed that females with the piwi mutation exhibited an adaptive effect of chronic irradiation in low dose (20 sGy) in response to subsequent exposure in dose 60 Gy. Chronic low-dose irradiation did not affect reproductive functions and the level of DNA damage in the gonads of individuals with dysfunction of the and genes, but led to an increase in their lifespan. Thus, a functional decrease in some genes of the family can modify the effects of irradiation with the formation of radioresistant traits in animals.