Computational analysis reveals catalytic conversion mechanisms in C(sp3)–H hydroxylation, indicating roles of alkali metals.
The mechanism of aerobic C(sp³)-H hydroxylation to α-hydroxy ketone is investigated by multiple quantum chemical computations. An alkali-metal-assisted electron transfer (AET) is proposed to drive the triplet-to-singlet transition for C-O bond formation. The O-O bond cleavage is the key to catalytic conversion, which depends on different alkali metal bases and reductants.
No takes yet. Share an insight, caveat, or question.
Li et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: