Integration of single-cell sequencing and in vivo experiments shows UBE2H impacts immune microenvironment in pancreatic cancer, suggesting new treatment strategies.
This study revealed the presence of a UBE2H+ cell population within the pancreatic ductal cell niche and analyzed the inhibition of UBE2H on the immune microenvironment of pancreatic cancer through single-cell sequencing and in vivo experiments, providing important clues for the formation of "cold" tumors in pancreatic cancer and opening new directions for exploring new treatment strategies.
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Huang et al. (2025) studied this question.
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