Enoxaparin improves trophoblast function by enhancing PAX3 expression through methylation in preeclampsia, suggesting a new therapeutic target.
Enoxaparin mitigated PE progression by upregulating NSUN2, which enhanced PAX3 expression via site-specific m⁵C methylation, thereby improving trophoblast function. The NSUN2/m⁵C/PAX3 axis represents a novel mechanistic insight and potential therapeutic target for PE.
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Zhong et al. (2025) studied this question.
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