SIRT5 enhances osteogenic differentiation and fracture healing in BMSCs, suggesting a role in skeletal disorders.
SIRT5 promotes osteogenic differentiation of BMSCs and enhances fracture healing by modulating BMP2 succinylation. These findings suggest that SIRT5 could be a potential therapeutic target for the treatment of bone fractures and other skeletal disorders.
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Gu et al. (2025) studied this question.
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