MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport status

Ouyang Ji; Yingxin Xie; Yunyao Lin; Ruolin Li; Yan Tong; Pu Li; Junyan Fang; Yingli Liu

doi:10.1186/s12882-025-04587-1

November 24, 2025BMC NephrologyOpen Access

MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport status

View Full Paper

Ask AI

Bookmark

Share

Key Points

Cell cycle arrest occurs in peritoneal mesothelial cells influenced by inflammatory factors, and impaired solute transport.
Key evidence shows that high peritoneal solute transport status relates to increased inflammation and fibrotic processes.
Analysis of cell responses to inflammatory stimuli highlights the involvement of miR-503-5p in mediating cell cycle impacts.
Implications point to the need for potential interventions addressing inflammation and fibrosis in patients with PD.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Observational findings show cell cycle arrest in mesothelial cells with high PSTR, indicating inflammatory factors may enhance fibrosis risk.

Abstract

Patients with PD who had a high PSTR exhibited an elevated inflammatory state, and the presence of inflammatory factors stimulated the upregulation of miR-503-5p expression, which led to cell cycle arrest in PMCs and promoted peritoneal fibrosis development.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79dd3 https://doi.org/10.1186/s12882-025-04587-1

View Full Paper

Ask AI

Bookmark

Share

MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport status

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

MiR-503-5p mediates cell cycle arrest and fibrosis of peritoneal mesothelial cells with a high peritoneal solute transport status

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading