c9, t11-Conjugated Linoleic Acid Supplementation Improves Cognitive Memory in ω-3 Polyunsaturated Fatty Acid-Deficient Mice

Weitao Ji; Hai-qin Chen; Lu-Lu Chang; Bo Yang; Jianxin Zhao; Ding Jiuhong; Wei Chen

doi:10.1039/d5fo03812j

January 1, 2025Food & Function

c9, t11-Conjugated Linoleic Acid Supplementation Improves Cognitive Memory in ω-3 Polyunsaturated Fatty Acid-Deficient Mice

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Key Points

Cognitive memory improved, indicating a positive effect from c9,t11-CLA supplementation.
Polyunsaturated fatty acids are essential for brain function, with long-chain variants linked to cognitive health.
Investigation of the gut microbiota's role in the neuroprotective effects of c9,t11-CLA supplementation was central to the study.
Findings highlight the need for further exploration into dietary modifications for brain health.

Implication

The research demonstrates improved cognitive memory in omega-3 fatty acid-deficient mice, suggesting c9,t11-CLA may support brain health.

Abstract

Long-chain polyunsaturated fatty acids (LC-PUFAs) are vital for brain health, with cis9, tran11-conjugated linoleic acid (c9, t11-CLA) showing neuroprotective effects. This study investigated the impact of gut microbiota-converted c9, t11-CLA...

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Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79e19 https://doi.org/10.1039/d5fo03812j

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c9, t11-Conjugated Linoleic Acid Supplementation Improves Cognitive Memory in ω-3 Polyunsaturated Fatty Acid-Deficient Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

c9, t11-Conjugated Linoleic Acid Supplementation Improves Cognitive Memory in ω-3 Polyunsaturated Fatty Acid-Deficient Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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