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January 1, 2025RSC AdvancesOpen Access

Synthesis of benzylic thioether containing α-substituted thio compounds via carbene insertion into an S–H bond: expeditious access to a new C–S bond

Arumugam Jayarani Gruhapriya Jelakam Chinnappan Sivasankar Arumugam Jayarani Gruhapriya Jelakam Chinnappan Sivasankar

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Key Points

Thioethers play a significant role in biological systems, expanding their applications across various fields.
The process effectively synthesizes thio compounds, providing new avenues for exploration within this chemistry.
Analysis of carbene insertion into S–H bonds facilitates the formation of C–S bonds in thio compound synthesis.
This method may enable improved strategies for the production of biologically relevant thioethers.

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Implication

This research demonstrates thioethers synthesis in biological systems, indicating a novel method for producing thio compounds.

Abstract

Considering the importance of thioethers in biological systems, we developed a strategy to achieve these target molecules.

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Cite This Study

Jayarani et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a4ca https://doi.org/10.1039/d5ra06843f

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