Observational analysis reveals higher kappa-free light chain levels associate with cortical damage in multiple sclerosis, indicating potential as a biomarker.
Higher κ-FLC levels were associated with both PVL burden and cortical pathology, regions adjacent to the CSF. Although this study was limited by a relative small sample size, our findings underscore the potential of κ-FLC as a diagnostic and prognostic MS biomarker.
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Damulina et al. (2025) studied this question.
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