Research reveals Sox2's chromatin functions in retinal progenitor cells, highlighting epigenetic roles in development.
During mammalian eye development, Sox2 is involved in the gene regulatory network that helps retinal progenitor cells (RPCs) gain neural competence, but how it mechanistically contributes to this process is unclear. In a new study, Issam Al Diri and colleagues address this and unravel the chromatin-based functions of SOX2 in the developing retina. To learn more about this work and the people behind it, we talked to first authors Fuyun Bian, Kimiasadat Golestaneh, Emily Davis and Abdullah Khan from the Retinal Epigenetics and Genomics Laboratory at the UPMC Vision Institute, University of Pittsburgh, PA, USA.
No takes yet. Share an insight, caveat, or question.
A 2024 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: