CLIC3 emerges as a novel prognostic biomarker and therapeutic target in triple-negative breast cancer through integrated multi-omics analysis

Shuai Yuan; Jiangxia Li; Weimei Liu; Meitian Ren; Lianyu Lin; Shuangying Hao; Lina Yang; Shuai Yuan; Jiangxia Li; Weimei Liu; Meitian Ren; Lianyu Lin; Shuangying Hao; Lina Yang

doi:10.1186/s12885-025-15205-6

November 26, 2025BMC CancerOpen Access

CLIC3 emerges as a novel prognostic biomarker and therapeutic target in triple-negative breast cancer through integrated multi-omics analysis

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Key Points

Inhibition of CLIC3 reduces aggressiveness in triple-negative breast cancer, providing new therapeutic avenues.
The study identifies CLIC3 as a prognostic biomarker linked to clinical outcomes in TNBC patients.
Integrated analysis of omics data highlighted CLIC3's role in driving TNBC pathology and treatment responses.
These insights support further exploration of CLIC3-targeted therapies for improved patient management.

Implication

Multi-omics analysis reveals CLIC3 as a key biomarker in triple-negative breast cancer, indicating its potential as a therapeutic target.

Abstract

CLIC3 is a TNBC-specific prognostic biomarker and therapeutic target. Its inhibition impedes TNBC aggressiveness, providing a foundation for targeted therapy development.

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Cite This Study

Yuan et al. (2025) studied this question.

synapsesocial.com/papers/692b943e1d383f2b2a37899f https://doi.org/10.1186/s12885-025-15205-6

View Full Paper

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CLIC3 emerges as a novel prognostic biomarker and therapeutic target in triple-negative breast cancer through integrated multi-omics analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

CLIC3 emerges as a novel prognostic biomarker and therapeutic target in triple-negative breast cancer through integrated multi-omics analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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