Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells

Cui Du; Hairui Fan; Jiayao Jiang; Juan Yang; Shuai Chen; Nadezhda E. Vorobyeva; Congrui Zhu; Li-ming Mao; Chenxi Li; Yanhua Li; WenBin Bao; Ming‐an Sun; Cui Du; Hairui Fan; Jiayao Jiang; Juan Yang; Shuai Chen; Nadezhda E. Vorobyeva; Congrui Zhu; Li-ming Mao; Chenxi Li; Yanhua Li; WenBin Bao; Ming‐an Sun

doi:10.1186/s12864-025-12285-3

Key Points

Monocytes express genes influenced by transposable elements, highlighting their regulatory function.
Integrative analysis shows the role of transposable elements in monocyte enhancers across species.
Multiomic assessments of immune cells reveal the significant role of transposable elements in gene regulation.
Findings suggest that transposable elements contribute to unique gene expression patterns among immune cells.

Implication

Integrative analysis reveals transposable elements enhance gene expression in monocytes, indicating their role in immune responses.

Abstract

Here, we characterized the highly cell-specific profile of TE-derived CREs in different types of human blood immune cells. Integrative analysis further demonstrates the frequent contribution of TEs in creating monocyte enhancers including those specific for human or mouse, and indicates the potential involvement of TEs in mediating species-specific monocyte gene expression.

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Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/692b944c1d383f2b2a378c51 https://doi.org/10.1186/s12864-025-12285-3

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Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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