Edaravone attenuates doxorubicin-induced oral mucosal injury via modulation of oxidative stress, inflammatory signaling, and the SIRT1/TLR4/NF-kB/ACE2 axis in rats

Mert Zeytinoğlu; Aras Erdil; Sefa Çolak; Mustafa Sami Demirsoy; Ali Tuğrul AKIN; Necla DEĞER; Derya Karabulut; Serdar Savaş Gül; Hatice AYGÜN; Oytun Erbaş; Mert Zeytinoğlu; Aras Erdil; Sefa Çolak; Mustafa Sami Demirsoy; Ali Tuğrul AKIN; Necla DEĞER; Derya Karabulut; Serdar Savaş Gül; Hatice AYGÜN; Oytun Erbaş

doi:10.1186/s12903-025-07148-y

Key Points

Edaravone significantly mitigates oral mucosal injury caused by doxorubicin, improving healing processes.
Key metrics include modulation of oxidative stress and inflammatory signaling pathways, enhancing recovery.
Assessment of the SIRT1/TLR4/NF-kB/ACE2 axis demonstrates edaravone's multifaceted protective role.
Findings suggest that edaravone may serve as a promising treatment option for mucosal protection against chemical injury.

Implication

Observational analysis reveals edaravone's therapeutic potential in mitigating doxorubicin-induced mucosal injury, highlighting its impact on SIRT1 and ACE2 pathways.

Abstract

Edaravone effectively attenuates DOX-induced mucosal injury by modulating oxidative stress, inflammatory signaling, and TLR4/ACE2 pathways, suggesting therapeutic potential in mucosal protection.

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Cite This Study

Zeytinoğlu et al. (2025) studied this question.

synapsesocial.com/papers/692b944c1d383f2b2a378cd4 https://doi.org/10.1186/s12903-025-07148-y

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Edaravone attenuates doxorubicin-induced oral mucosal injury via modulation of oxidative stress, inflammatory signaling, and the SIRT1/TLR4/NF-kB/ACE2 axis in rats

Key Points

Implication

Abstract

Discussion

Cite This Study

Edaravone attenuates doxorubicin-induced oral mucosal injury via modulation of oxidative stress, inflammatory signaling, and the SIRT1/TLR4/NF-kB/ACE2 axis in rats

Key Points

Implication

Abstract

Discussion

Cite This Study

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