November 30, 2025CellsOpen Access

Reciprocal Paracrine Signaling and Dynamic Coordination of Transitional States in the Alveolar Epithelial Type 2 Cells and Associated Alveolar Lipofibroblasts During Homeostasis, Injury and Repair

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Single-cell RNA-sequencing reveals homeostasis and repair mechanisms in alveolar cells, highlighting potential antifibrotic targets like metformin.

Repair enhances pulmonary function while inhibiting fibrosis in alveolar cells and myofibroblasts.
Alveolar epithelial type 2 cells transition dynamically during lung injury and repair processes, supporting regeneration.
Inhibition of profibrotic pathways can restore alveolar differentiation with promising compounds such as metformin.
The findings underscore the importance of epithelial and mesenchymal plasticity in chronic lung disease therapies.

Panagiotidis et al. (2025) studied this question.

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November 30, 2025CellsOpen Access

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Authors

Single-cell RNA-sequencing reveals homeostasis and repair mechanisms in alveolar cells, highlighting potential antifibrotic targets like metformin.

Repair enhances pulmonary function while inhibiting fibrosis in alveolar cells and myofibroblasts.
Alveolar epithelial type 2 cells transition dynamically during lung injury and repair processes, supporting regeneration.
Inhibition of profibrotic pathways can restore alveolar differentiation with promising compounds such as metformin.
The findings underscore the importance of epithelial and mesenchymal plasticity in chronic lung disease therapies.

Panagiotidis et al. (2025) studied this question.

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