Cohort study shows elevated serum CYFRA21-1 predicts pulmonary fibrosis in interstitial lung disease, implying effective risk stratification.
Elevated serum CYFRA21-1 levels independently predict the development of PPF in patients with non-IPF ILD. It is correlated with impaired pulmonary function and radiographic severity. CYFRA21-1 may serve as a valuable biomarker for early risk stratification, supporting the need for validation in prospective multicentre studies.
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Zhang et al. (2025) studied this question.
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