Transcriptomic profiling shows dysregulation in extracellular matrix and lipid metabolism in DYT-TOR1A dystonia, indicating underlying neurodevelopment mechanisms.
Our study in iPSC-derived from DYT-TOR1A patients shows a transcriptomic profile, which validates previous candidate genes highlighted in other animal models of dystonia. We believe that our results will help elucidate early mechanisms in neurodevelopment of DYT-TOR1A dystonia.
No takes yet. Share an insight, caveat, or question.
Setó‐Salvia et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: