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Case report reveals progression to gastric cancer in a patient with chronic hepatitis B, suggesting need for surveillance and intervention.
We present the case of a 49-year-old man with cirrhosis secondary to chronic hepatitis B and a history of Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma, who was later found to have an incidental early-stage signet ring cell adenocarcinoma during surveillance. This case highlights the role of chronic inflammation in gastric carcinogenesis and underscores the importance of long-term endoscopic monitoring and the utility of endoscopic submucosal dissection in appropriately selected patients.
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Pinkert et al. (2025) studied this question.
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