Case report reveals de novo dyschromatosis symmetrica hereditaria in a 26-year-old female, suggesting unique genetic implications in treatment decisions.
A BSTRACT Dyschromatosis symmetrica hereditaria (DSH), is an autosomal dominant (AD) genetic disorder with a significant permeation, primarily referred to as reticulate acropigmentation of Dohi. It is distinguished by hyper- and hypopigmented macules of varying dimensions on the dorsal surface of the extremities with reticulated patterns. Thus, it is imperative to delve into a differential diagnosis involving numerous pigmentary disorders considering this specific disorder is uncommon in Asians, with a substantial number of instances described in Japanese origin. Given that it is a benign ailment, it is critical to understand the diagnosis to recommend appropriate treatment to those affected. We report this rare case in a 26-year-old female of de novo origin not associated with any other systemic disease.
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Iqbal et al. (2025) studied this question.
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