Aims The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio reflects the balance between atherogenic and anti-atherogenic lipid fractions. The study aims to investigate the utility of the TG/HDL-C ratio in identifying high-risk groups for cardiovascular disease (CVD) within the general population. Methods The current study was a branch of the ChinaHEART cohort in middle China that involved a total of 6,593 community-dwelling adults. We examine the association between TG/HDL-C and CVD high-risk in a cross-sectional investigation. Results Results from restricted cubic spline and ROC analyses revealed a significant relationship between higher TG/HDL-C levels and increased odds of CVD high-risk, with the ratio exhibiting good discriminatory power (AUC = 0.820 in the fully adjusted model). Logistic regression further supported this association, indicating a 1.21-fold rise in the odds of high risk for each unit increase in TG/HDL-C. Conclusions The TG/HDL ratio shows promise for CVD risk assessment. Incorporating the TG/HDL ratio into risk assessment models may provide supplementary information to healthcare professionals for risk stratification.
Li et al. (2025) studied this question.