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January 1, 2025RSC AdvancesOpen Access

From amides to thioamides: understanding enhanced anion binding in acyclic receptors

Siebe Lekanne Deprez Senuri G. Jayawardana Célia Fonseca Guerra

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Key Points

Enhanced anion selectivity observed with thioamide receptors compared to amide ones, indicating stronger binding.
Key evidence shows that thioamide receptors displayed increased anion binding due to hydrogen bonds.
Analysis revealed that conformation plays a crucial role in the performance of receptors in anion binding.
Hydrogen bonds may significantly improve receptor efficacy, suggesting novel pathways for receptor design.

Implication

Analysis reveals enhanced anion selectivity in thioamide receptors compared to amides, highlighting hydrogen bonds' significance.

Abstract

Anion selectivity of amide- and thioamide-based receptors determined by conformation and hydrogen bonds.

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Cite This Study

Deprez et al. (2025) studied this question.

synapsesocial.com/papers/692e3d706c9b3ab28c186ec0 https://doi.org/10.1039/d5ra08433d

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