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December 2, 2025Frontiers in ImmunologyOpen Access

Efgartigimod for the treatment of immune checkpoint inhibitor-associated myocarditis complicated with impending crisis state of myasthenia gravis: a case report

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Authors

JSJing Sha

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Overview

Case report shows efgartigimod improves myasthenia gravis symptoms and reduces troponin levels, indicating effective salvage therapy for myocarditis.

Key Points

  • Salvage therapy with efgartigimod improved clinical symptoms and lab markers in a 69-year-old woman.
  • Troponin T and troponin I levels were significantly elevated, indicating myocarditis alongside myasthenia gravis exacerbation.
  • Prednisone acetate treatment reduced myocardial enzymes, enhancing recovery from myocarditis and associated liver injury.
  • Early recognition of immune-related adverse events is crucial for improving patient outcomes in complex cases.

Cite This Study

Jing Sha (2025) studied this question.

synapsesocial.com/papers/692e3d706c9b3ab28c186f49https://doi.org/10.3389/fimmu.2025.1671964
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Case report: Efgartigimod combined with intravenous methylprednisolone in a case of co-occurrence of unexplained myasthenia gravis, inflammatory myopathy, and fulminant myocarditis2026
  2. 2Fatal Myocarditis Relapse in a Patient with Myasthenia Gravis Treated with Efgartigimod Alfa: A Case Report2026
  3. 3Efgartigimod as Rescue Therapy for PD-1 Inhibitor–Associated Myasthenia Gravis, Myocarditis, and Myositis (MMM) Syndrome: A 2-Case Report and Literature Review2026 · 1 citations
  4. 4Efficacy and safety of efgartigimod in the treatment of impending myasthenic crisis2026 · 1 citations
  5. 5Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study2025 · 11 citations