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Analysis demonstrates improved diagnostic yield for prenatal congenital heart disease linked to maternal diabetes, highlighting gene-environment interactions.
Concurrent implementation of CMA and WES substantially enhances diagnostic yield in prenatal CHD detection associated with maternal diabetes. Our data demonstrates significant gene-environment interactions wherein maternal hyperglycemia potentiates phenotypic expression of cardiac developmental gene variants, elucidating pathogenetic mechanisms and supporting individualized risk stratification.
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Cao et al. (2025) studied this question.
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