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December 2, 2025Journal of Translational Medicine2 citationsOpen Access

Booster dose reshapes SARS-CoV-2 RBD-specific B cell immunity in people living with HIV

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MTMario Tumbarello

Key Points

  • Booster dose improves B cell immunity in people living with HIV, enhancing vaccine response durability.
  • The study highlights the role of specific biomarkers in predicting long-term immune response.
  • Observational analysis focused on clinical and demographic variables related to MBC persistence.
  • These findings may enable targeted vaccination strategies for individuals with HIV.

Abstract

These findings highlight the impact of boosting, particularly the third dose, in enhancing and shaping the RBD-specific MBC in PLWH. Clinical and demographic variables associated with long-term MBC persistence may serve as potential biomarkers for predicting durable vaccine responses in PLWH.

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Cite This Study

Mario Tumbarello (2025) studied this question.

synapsesocial.com/papers/692e3d846c9b3ab28c1874b8https://doi.org/10.1186/s12967-025-07414-1
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