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December 2, 2025Journal of Neuroinflammation2 citationsOpen Access

Reprogramming autoimmunity: inducing antigen-specific tolerance via apoptotic mimicry in an experimental model of multiple sclerosis

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MVMarta Vives‐Pi

Key Points

  • Antigen-specific therapy with PS liposomes effectively expands Treg cells, improving autoimmune regulation.
  • Observational analysis demonstrates modulation of the inflammatory immune response to MOG, promoting tolerance.
  • Therapeutic reprogramming focuses on harnessing apoptotic mimicry for enhancing immune plasticity in MS.
  • This approach may enable safer treatments in multiple sclerosis, guiding future clinical applications.

Abstract

Our findings indicate that antigen-specific therapy with PS liposomes mimicking apoptotic bodies downregulates the MOG-specific inflammatory immune response and expands Breg and Treg cells, offering a safe, versatile, and easily applicable approach that strongly supports its potential for near-future clinical translation in MS.

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Cite This Study

Marta Vives‐Pi (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c18764fhttps://doi.org/10.1186/s12974-025-03618-w
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