Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors

Brian T. Bateman

doi:10.1186/s12916-025-04475-3

November 28, 2025BMC MedicineOpen Access

Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors

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Key Points

Initiating hydrocodone with selective serotonin reuptake inhibitors increases overdose risk.
Opioid overdose risk was particularly notable with citalopram, escitalopram, and paroxetine.
Cohort study utilized US healthcare claims databases for analysis.
Findings indicate need for careful monitoring when prescribing these medications together.

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Implication

Cohort study revealed opioid overdose risk increases with hydrocodone and SSRIs like citalopram and fluoxetine, suggesting caution is necessary.

Abstract

In this cohort study, based on data from US healthcare claims databases, initiating citalopram, escitalopram, fluoxetine, or paroxetine while on hydrocodone was associated with an increased risk of opioid overdose compared with sertraline. No substantial risk differences were observed across SSRIs other than sertraline.

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Cite This Study

Brian T. Bateman (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c18773d https://doi.org/10.1186/s12916-025-04475-3

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Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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