Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway

Qinghua Wang; Yujing Shi; Hui Song; Muxing Li; Yuyu Sun; Longju Qi

doi:10.1186/s13287-025-04794-5

November 28, 2025Stem Cell Research & TherapyOpen Access

Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway

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Key Points

Motor function shows significant improvement in spinal cord injury with combined therapies.
Exosomes from menstrual blood-derived stem cells paired with treadmill training enhance recovery.
Analysis involves exosomes promoting tissue repair while reducing fibrosis post-injury.
Therapeutic synergy points to novel treatments for spinal cord injury recovery.

Implication

Observational analysis highlights motor recovery in SCI through exosomes and PI3K/Akt pathway activation.

Abstract

MenSCs-Exo combined with WSTT synergistically enhances motor recovery after SCI by promoting tissue repair, reducing fibrosis, and activating the PI3K/Akt pathway. This cell-free therapy paired with rehabilitation exercise offers a novel strategy for SCI treatment.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c187770 https://doi.org/10.1186/s13287-025-04794-5

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Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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