Neurological presentation of lymphoma: Report of six cases

Primary or secondary lymphomas of the central nervous system may present with various focal or nonfocal neurologic signs and symptoms depending on the location and size of the lesions in the brain and the amount of surrounding edema and mass effect. The most common of these symptoms are cranial nerve deficits, but mental status changes, focal weakness, sensory loss, epileptic seizures, increased intracranial pressure, headache, and radicular pain may also be observed. However, neurological presentations of lymphomas are rare. The diagnosis may be challenging due to the various involvement patterns both clinically and radiologically. Although biopsy is the gold standard method in diagnosis, cerebrospinal fluid cytopathology and flow cytometry are useful in detecting hematological malignancy in the cerebrospinal fluid. Herein, we reported six cases of lymphoma with neurologic presentation.