Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Xinxin Wang; Qiuyan Li; Wenbo Pang; Jianhua Yin

doi:10.1038/s43856-025-01220-y

November 28, 2025Communications MedicineOpen Access

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

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Key Points

Identification of biomarkers for age-related and sex-biased diseases improves health monitoring potential.
Study shows specific associations with diabetes and autoimmune diseases using cell-free DNA.
Experimental profiling focuses on DNA methylation signatures in human plasma samples.
Findings highlight the significance of methylation as a novel health monitoring tool.

Implication

Analysis reveals biomarkers linked to diabetes and autoimmune diseases in cell-free DNA, suggesting health monitoring potential.

Abstract

Our discovered CpGs and genes help to explain age-related and sex-biased diseases such as psychiatric disorders, diabetes, and autoimmune diseases, and we demonstrate the potential of cfDNA methylation signatures as very promising biomarkers for health monitoring for the general population.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/692e3d986c9b3ab28c187a98 https://doi.org/10.1038/s43856-025-01220-y

View Full Paper

Ask AI

Bookmark

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Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Key Points

Implication

Abstract

Discussion

Cite This Study

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Key Points

Implication

Abstract

Discussion

Cite This Study

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