December 4, 2025Stem Cell Research & Therapy8 citationsOpen Access

Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

HKHaiyang KouXi'an Honghui Hospital WZWeijie ZhangXi'an Honghui Hospital JMJianbing MaShanxi Medical University

Key Points

Curcumin enhances therapeutic effects in osteoarthritis by controlling senescence in stem cells, indicating its potential utility.
The most significant mechanism observed was autophagy regulation linked to FoxO3 signaling affecting stem cell behavior.
Assessment using curcumin-pretreated adipose-derived mesenchymal stem cells delivered via intra-articular injection for joint health.
This highlights curcumin's potential in osteoarthritis treatment but calls for further studies on clinical efficacy.

Abstract

Curcumin controls ADSC senescence via the FoxO3-mediated signaling pathway, and FoxO3 directly regulates Becnl to induce autophagy. Intra-articular injection of curcumin-pretreated ADSCs enhances joint homeostasis for OA treatment. This study provides evidence for the potential clinical application of curcumin-pretreated ADSCs in enhancing the therapeutic effects of OA treatment.

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Kou et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1cb5 https://doi.org/10.1186/s13287-025-04836-y

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December 4, 2025Stem Cell Research & Therapy8 citationsOpen Access

Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

View Full Paper

HKHaiyang KouXi'an Honghui Hospital WZWeijie ZhangXi'an Honghui Hospital JMJianbing MaShanxi Medical University

Key Points

Curcumin enhances therapeutic effects in osteoarthritis by controlling senescence in stem cells, indicating its potential utility.
The most significant mechanism observed was autophagy regulation linked to FoxO3 signaling affecting stem cell behavior.
Assessment using curcumin-pretreated adipose-derived mesenchymal stem cells delivered via intra-articular injection for joint health.
This highlights curcumin's potential in osteoarthritis treatment but calls for further studies on clinical efficacy.

Abstract

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Cite This Study

Kou et al. (2025) studied this question.

synapsesocial.com/papers/6930dc5fea1aef094cca1cb5 https://doi.org/10.1186/s13287-025-04836-y

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