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December 4, 2025Physiological ReportsOpen Access

Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats

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Authors

ARAntônio Augusto Coppi Maciel Ribeiro

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Overview

Excessive fructose during pregnancy alters fetal growth and kidney function in females, suggesting maternal nutrition impacts future metabolic diseases.

Key Points

  • High maternal fructose intake leads to sex-specific alterations in kidney function.
  • Females exhibited significant increases in water retention and liver fat accumulation due to prenatal fructose exposure.
  • Observational study in rats demonstrated effects on placental structure and offspring health from maternal nutrition.
  • Findings highlight the link between prenatal diet and future risks of noncommunicable diseases.

Cite This Study

Antônio Augusto Coppi Maciel Ribeiro (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca1f60https://doi.org/10.14814/phy2.70684
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Also Consider

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  1. 1Fructose consumption in pregnancy and associations with maternal and offspring hepatic and whole-body adiposity: a scoping review.2024
  2. 2Cardiac Hypertrophy in Pregnant Rats, Descendants of Fructose-Fed Mothers, an Effect That Worsens with Fructose Supplementation2024 · 1 citations
  3. 3Impact of Fructose‐Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats2025
  4. 4Nutrigenomic effects of fructose alone or associated with cholesterol or salt on thyroid hormone function. Influence of maternal intake2024
  5. 5Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring2025