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December 4, 2025Drug Development ResearchOpen Access

Study on the Mechanism of Aspirin Alleviating Kawasaki Disease With Coronary Artery Lesions by Inducing TRAF6 to Regulate STAT3 Ubiquitination and Inhibit Th17 Cell Differentiation

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Authors

XQXiangzhen QuChifeng UniversityWMWeina MaChifeng UniversityXMXiujie MaChengdu Sport University

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Implication

Observational analysis shows aspirin alters ubiquitination in Kawasaki disease, indicating potential pathways for treatment.

Key Points

  • Aspirin treatment improved Kawasaki disease with coronary artery lesions through interaction effects.
  • Increased levels of TRAF6 and reduced STAT3 were specifically linked to Th17 cell regulation.
  • Analysis utilized RT-qPCR and western blot techniques on samples from healthy and Kawasaki disease children.
  • Findings suggest that aspirin promotes TRAF6 function, impacting STAT3 ubiquitination and Th17 differentiation.

Cite This Study

Qu et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca21d3https://doi.org/10.1002/ddr.70199
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