Research shows targeting immune-microenvironment dynamics improves outcomes in colorectal cancer, suggesting progress for immunotherapy strategies.
Special consideration is directed toward the translational value of targeting immune-metabolic interactions and spatial dynamics within the TME. Ultimately, this work synthesizes current knowledge and outlines forward-looking strategies to advance personalized, multi-target immunotherapy, with the potential to reshape clinical paradigms in CRC management.
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Xia et al. (2025) studied this question.
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