Higher INHBB expression indicates poor prognosis in colorectal carcinoma, suggesting it as a biomarker for immune evasion in cancer progression.
INHBB is predominantly expressed in tumor epithelium and is associated with aggressive features, poor prognosis, and the formation of an immune-cold, macrophage-rich TME in CRC. These findings suggest that INHBB may be a potential biomarker for immune evasion and a target for novel immunotherapeutic strategies in CRC.
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Sawaguchi et al. (2025) studied this question.
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