December 4, 2025Intensive Care MedicineOpen Access

Temporal robustness of biomarker-based classification algorithms for sepsis

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Analysis reveals instability in immune profiles in sepsis patients, suggesting biomarkers may need reevaluation for clinical use.

Reclassification of immune profiles occurred frequently in sepsis patients, indicating a need for stable biomarkers.
Approximately one-third of subgroup peers changed with each timepoint, pointing to inconsistencies in classification.
Observational analysis across short intervals highlighted the challenges of biomarker-derived endotypes for sepsis.
This instability calls for further investigation to improve clinical utility and reliability of sepsis classifications.

Rademaker et al. (2025) studied this question.

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