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This is a In Vitro Study study.

December 4, 2025Scientific ReportsOpen Access

Ferulic acid-loaded chitosan nanoparticles enhance radiotherapy efficacy via STAT3 suppression and caspase-8/p53 activation in Ehrlich ascites carcinoma

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Combination therapy reduced tumor mass by 44.3% and volume by 67.0% in EAC, indicating significant antitumor effects.
Molecular analysis showed a 70% suppression of STAT3 and 108.2% activation of caspase-8, with p53 stabilization enhancing radiotherapy efficacy.
Synthesis of ferulic acid-loaded chitosan nanoparticles employed ionic gelation and comprehensive characterization for optimal properties.
The approach highlights potential for improved treatment options for resistant cancers with significant biomedical implications.

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Combination therapy improves tumor progression in Ehrlich ascites carcinoma, suggesting ferulic acid enhances radiosensitization.

Mansour et al. (2025) studied this question.

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