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December 4, 2025Acta Neurochirurgica4 citationsOpen Access

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial

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KLKimmo LönnrotUniversity of HelsinkiVLVille LeinonenTampere University

Key Points

  • Nearly 14% of patients died after surgery, often due to circulatory diseases and dementia, indicating significant mortality risk.
  • Mortality data collected from Statistics Finland revealed a median follow-up of 16.4 months with a median age at death of 85 years.
  • The analysis focused on patients from the FINISH randomized trial, examining associations between comorbidities and mortality outcomes.
  • The findings underscore the importance of managing pre-existing comorbidities like hypertension and cardiac arrhythmia in surgical patients.

Abstract

Abstract Purpose Chronic subdural hematoma (CSDH) is a common neurosurgical disease, especially prevalent among the elderly and is associated with reduced life expectancy. This study investigated mortality and causes of death after burr-hole drainage surgery for CSDH. Methods We included patients from the FINISH trial, a national, multicenter, randomized study conducted in Finland during 2020–2022. We obtained mortality data from Statistics Finland. For the classification of causes of death, we used the European shortlist of 86 causes, which is derived from the 10th revision of the International Classification of Diseases and Related Health Problems (ICD-10). Results Overall, the FINISH trial population included 589 patients (median age 78 years, 28% women). After a median follow-up of 16.4 months (IQR 9.7–23.1), 82 patients (14%) died. The median age at death was 85 years (IQR 81–89), and the median time from surgery to death was 6.5 months (IQR 2.4–15.3). The leading causes of death were circulatory diseases (34%), accidents (16%), and dementia (15%). A higher number of pre-existing comorbidities was significantly associated with increased mortality. In particular, dementia, cardiac arrhythmia, prior cerebrovascular events, and hypertension emerged as significant risk factors for death. Conclusion This study provides valuable insights into mortality rates and causes of death among patients undergoing CSDH surgery. The findings underscore the critical role of pre-existing comorbidities in influencing patient outcomes. Trial Registration The FINISH trial was registered with ClinicalTrials.gov (NCT04203550) on Dec 16, 2019. The trial is completed.

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Cite This Study

Lönnrot et al. (2025) studied this question.

synapsesocial.com/papers/6930e8b6ea1aef094cca2fd1https://doi.org/10.1007/s00701-025-06728-9
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