Observational analysis reports bioequivalence and serum concentration increases after intravenous calcium dosing during cesarean delivery, highlighting critical dosing variabilities.
( Anesthesiology . 2025;142:121-131. doi: 10.1097/ALN.0000000000005248) Intravenous calcium gluconate (CaGluc) and calcium chloride (CaCl) are often used by anesthesiologists and can be administered for a variety of clinical indications. It is frequently used both on and off-label, and there are few studies that evaluate pharmacokinetics of intravenous calcium in either form, with misunderstandings about bioequivalence between the two forms leading to adverse outcomes and even death. This study was designed to report the pharmacokinetics of the acute time course of increased serum ionized calcium concentration after intravenous administration and answer the questions of bioequivalence in dosing, amount increased in serum per 1 g dose of medication, and time course of serum concentration after one dose.
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Ansari et al. (2025) studied this question.
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