Selenium-Containing Peptides Attenuating Pb-Induced Memory Impairment through Molecular Chelation and microRNA-Mediated Signaling

Fengjiao Fan; Nanlong Li; Wenqian Tang; Zhiyin Xiao; Xiaoyi Jiang; Peng Li; Jian Ding; Qinlu Lin; Yong Fang

doi:10.1039/d5fo04343c

January 1, 2025Food & Function

Selenium-Containing Peptides Attenuating Pb-Induced Memory Impairment through Molecular Chelation and microRNA-Mediated Signaling

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Key Points

Memory impairment links to oxidative stress from lead neurotoxicity in the hippocampus, highlighting a significant concern.
Successful intervention with selenium-containing peptides improves cognitive functions affected by lead exposure.
Analysis focuses on biochemical pathways involved in lead-induced memory loss via molecular chelation and microRNA signaling.
May enable better therapeutic strategies for counteracting lead toxicity effects on cognitive health.

Implication

Observational analysis shows neurotoxicity from Pb leads to oxidative stress in hippocampus, indicating treatment with selenium peptides may improve memory.

Abstract

Lead (Pb) accumulation in the hippocampus and subsequent induced oxidative stress contribute to memory impairments, highlighting the hippocampus as a primary target for Pb neurotoxicity. Selenium-containing peptides TSeMMM and SeMDPGQQ...

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Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/6930e8c6ea1aef094cca350a https://doi.org/10.1039/d5fo04343c

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Selenium-Containing Peptides Attenuating Pb-Induced Memory Impairment through Molecular Chelation and microRNA-Mediated Signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

Selenium-Containing Peptides Attenuating Pb-Induced Memory Impairment through Molecular Chelation and microRNA-Mediated Signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

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