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December 4, 2025CellsOpen Access

Advanced Glycation End Products Promote PGE2 Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC–NF-κB Pathway

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Authors

MOMisae OnoNTNatsuko TanabeRIRisa Ichikawa

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Overview

Experimental analysis shows AGEs enhance PGE2 levels in gingival cells, indicating links to periodontitis in diabetes.

Key Points

  • AGEs increased COX2 and PGE2 levels in Ca9-22 cells, indicating a role in inflammation.
  • PGE2 production raised significantly in AGEs-treated cells (n=5, p<0.05).
  • Inhibiting RAGE blocked AGEs effects on COX2 and PGE2, highlighting this pathway's importance.
  • Results suggest AGEs contribute to periodontitis severity in diabetes through inflammatory mediators.

Cite This Study

Ono et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3a2ahttps://doi.org/10.3390/cells14231911
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