Systematic review reveals interleukin-7 improves T cell counts in HIV patients on antiretroviral therapy, suggesting it may aid immune restoration.
Our analysis revealed that IL-7 can induce an increase in CD4⁺ and CD8⁺ T cell counts in individuals with HIV receiving long-term ART, aiding in immune system reconstitution and increasing the HIV DNA load in the whole blood. These findings suggest that while IL-7 holds promise as an adjuvant strategy for immune restoration, its long-term impact on HIV persistence must be weighed in clinical application.
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Deng et al. (2025) studied this question.
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