Utility of self-rated vs informant-rate AD8 (Ascertain Dementia 8) for detection of early cognitive impairment: Experience of a “real-world” memory clinic

Khin Khin Win; Justin Chew; Jun Pei Lim; Esther Ho; Noorhazlina Ali; Mark Chan; Wee Shiong Lim

doi:10.4235/agmr.25.0082

November 27, 2025Annals of Geriatric Medicine and ResearchOpen Access

Utility of self-rated vs informant-rate AD8 (Ascertain Dementia 8) for detection of early cognitive impairment: Experience of a “real-world” memory clinic

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Key Points

Early cognitive impairment detection is less effective using self-rated AD8 assessments, showing lower reliability.
Self-rated AD8's diagnostic performance is inferior compared to informant-rated AD8 for identifying early cognitive impairment.
The assessment occurred in a real-world memory clinic context, analyzing the utility of the AD8 scale in clinical practice.
Results indicate that self-rated measures may not be suitable as standalone diagnostic tools for early cognitive impairment.

Implication

Observational analysis shows self-rated AD8 has lower reliability and diagnostic performance for early cognitive impairment in a memory clinic, indicating informant-rate may be preferable.

Abstract

AD8-self has a distinct factor structure, lower reliability, and inferior diagnostic performance compared to AD8-informant for ECI/MCI detection. Our result do not support AD8-self as a standalone tool for detecting ECI or MCI.

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Cite This Study

Win et al. (2025) studied this question.

synapsesocial.com/papers/6932311e8e51979591dce2e1 https://doi.org/10.4235/agmr.25.0082

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Utility of self-rated vs informant-rate AD8 (Ascertain Dementia 8) for detection of early cognitive impairment: Experience of a “real-world” memory clinic

Key Points

Implication

Abstract

Discussion

Cite This Study

Utility of self-rated vs informant-rate AD8 (Ascertain Dementia 8) for detection of early cognitive impairment: Experience of a “real-world” memory clinic

Key Points

Implication

Abstract

Discussion

Cite This Study

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