Single-Molecule Nanopore Profiling of Protein Domain Fragment Dynamics and Aggregation

Dapeng Chen; Fei Zheng; Guangle Qin; LiChun Zou; Chaofan Ma; Wei Liu; Haiyan Wang; Jingjie Sha

doi:10.1039/d5an01140j

December 3, 2025The AnalystOpen Access

Single-Molecule Nanopore Profiling of Protein Domain Fragment Dynamics and Aggregation

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Key Points

Dynamics of protein domain fragments observed in environmental shifts, revealing significant behavior changes.
Key findings indicate dynamic behavior observed at the molecular level involving conformational information.
Observational analysis on protein fragments reveals insights into their conformational changes and aggregation.
Understanding protein dynamics may enable advancements in developing targeted therapeutic strategies.

Implication

Analysis shows dynamic behavior of protein fragments in response to environmental changes, indicating important conformational insights.

Abstract

Protein fragmentation offers an effective approach for resolving localized conformational information and mapping discrete structural domains, yet current techniques may miss their dynamic behavior under changing external environments. Here, we...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6932311e8e51979591dce44b https://doi.org/10.1039/d5an01140j

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Single-Molecule Nanopore Profiling of Protein Domain Fragment Dynamics and Aggregation

Key Points

Implication

Abstract

Discussion

Cite This Study

Single-Molecule Nanopore Profiling of Protein Domain Fragment Dynamics and Aggregation

Key Points

Implication

Abstract

Discussion

Cite This Study

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