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Chemoenzymatic synthesis achieved rhodexin A in 9 steps and sarmentogenin in 7 steps from 17-deoxycortisone, indicating efficient techniques.
Herein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable enzymatic C 14 –H α-hydroxylation, a Bestmann ylide-enabled one-step construction of the butenolide motif, a late stage Mukaiyama hydration, and a stereoselective C11 carbonyl reduction.
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Song et al. (2025) studied this question.
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